135 articles - From Friday Feb 21 2025 to Friday Feb 28 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Gut |
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Development of live biotherapeutic products: a position statement of Asia-Pacific Microbiota Consortium. The development of LBP should be approached with a strong emphasis on microbiological evaluation, clinical relevance, scientific mechanisms and safety at every stage. These measures are essential to ensure the safety, effectiveness and long-term success of the product. |
| Hepatology |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
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Meta-Analysis: Inverse Association Between Helicobacter pylori Infection and Eosinophilic Oesophagitis. Exposure to H. pylori was significantly associated with decreased odds of EoE/EE. As a stronger protective effect was found in more recent studies, the epidemiology of this association may evolve and deserve to be further monitored. |
| Gut |
Glucagon-like peptide-1 receptor agonist use is associated with a lower risk of major adverse liver-related outcomes: a meta-analysis of observational cohort studies. GLP-1RA use is associated with a lower risk of liver-related complications and hepatic decompensation in people with T2D. These findings suggest a role of GLP-1RAs in preventing liver-related complications beyond their beneficial cardiometabolic effects. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
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Clinical Trial: A Phase 2b Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-Cirrhotic MASH. In patients with pre-cirrhotic MASH, treatment with MK-3655 resulted in a modest reduction in LFC at 24 weeks. Clinical trial number EudraCT 2019-003048-63; NCT 04583423. |
Differential Characteristics and Survival Outcomes of Patients With Cirrhosis According to Underlying Liver Aetiology. Survival outcomes in patients with cirrhosis varied by aetiology and have changed over time, which should be taken into account for future practice guidelines and modelling studies. |
Multicentre Study of 10,369 Symptomatic Patients Comparing the Diagnostic Accuracy of Colon Capsule Endoscopy, Colonoscopy and CT Colonography. CCE is safe and accurate for the diagnosis of colorectal disease. In the suspected CRC pathway, its 'filter function' complements existing colorectal diagnostic services by creating additional capacity. |
Risk of Incident Type 2 Diabetes and Prediabetes in Patients With Direct Acting Antiviral-Induced Cure of Hepatitis C Virus Infection. The incidence rates of T2D and prediabetes remain substantial among patients after HCV eradication. Lifestyle modification, drug therapy and regular monitoring of glycemic status are crucial for patients at risk of developing T2D and prediabetes following HCV clearance. |
Women's Health Disorders in a Coeliac Disease Population After Diagnosis-A Nationwide Cohort Analysis. Women with coeliac disease have higher frequencies of subsequent women's health disorders related to ovarian function, menstruation, fertility and menopause. Clinicians should be aware of these associations to detect women's health disorders during longitudinal coeliac care and promptly refer for a multidisciplinary approach with obstetrics and gynaecology. |
| Am J Gastroenterol |
A Review of the Modified Multiplier of SES-CD (MM-SES-CD) and How to Use in Clinical Trials and Practice. The Modified Multiplier Simple Endoscopic Score for Crohn's Disease (MM-SES-CD), developed by multivariable logistic regression modelling, weighs the individual parameters of the SES-CD including disease distribution based on their prognostic values for achieving ER. The objective of this qualitative review is to provide guidance to clinicians and clinical trialists for how to use and interpret the MM-SES-CD. |
Efficacy of 1 L polyethylene glycol plus ascorbic acid with linaclotide versus senna for bowel preparation: A multicenter, endoscopist-blinded, randomized controlled trial (Apple trial). The linaclotide regimen was superior to the senna regimen in terms of BP efficacy without reducing tolerability. It can be a promising new option for BP, especially in patients at a high-risk of inadequate BP. |
Neoplasia detection via colonic surveillance among young individuals with MSH6 and PMS2-associated Lynch Syndrome. Among individuals with MSH6/PMS2-associated LS undergoing early colonoscopy, neoplasia was common, even in those under 30. Current recommendations suggesting delayed initiation of surveillance among such patients may lead to missed preventive opportunities. |
Patterns of HBV viremia change and HBsAg loss rate in patients without retreatment within 2 years after entecavir or tenofovir cessation. Patients who remained or transitioned to the inactive phase had a high HBsAg loss rate without retreatment within 2 years after NA cessation. |
| Clin Gastroenterol Hepatol |
Characterization of screening strategies for Lynch syndrome in Latin America. Our study provides real-world outcomes that highlight disparities in screening uptake and counseling referrals, illustrating the challenges that Latin American countries face in hereditary cancer syndrome screening. These results contribute to the rationale for designing effective screening strategies for LS, which may also be applicable to other hereditary cancer syndromes, ultimately. |
Cost-Effectiveness of Lynch Syndrome Identification Strategies in Individuals with Colorectal Cancer and the Impact on At-Risk Relatives. The decrease in CRC incidence across generations can be used to facilitate discussions with relatives to improve uptake of CT. Further studies to optimize the uptake of CT are paramount to decrease risk of CRC in LS. |
Gallbladder cancer and dysplasia in cholecystectomy specimens: A large study in high-incidence regions of South America. These recruitment-site specific risk factors may help refine current prevention strategies by prioritizing prophylactic cholecystectomy in high-risk patients. The approach used in this study may guide future investigations on GBC prevention in high-incidence, low-income regions. |
| Endosc Int Open |
Application of EUS or MRCP prior to ERCP in patients with suspected choledocholithiasis in clinical practice. This study shows that stratification according to the ESGE guideline is useful to reduce the number of unnecessary additional imaging procedures and ERCPs in patients with a suspicion of choledocholithiasis. It seems worthwhile to perform EUS prior to ERCP in the same session. |
Day before late regimen vs standard split dose of low-volume PEG-CS for early morning colonoscopy: Multicenter randomized controlled trial. Albeit more tolerable, the DBL regimen was less effective than the SD regimen with regard to successful bowel cleansing for colonoscopies between 8 am and 10 am. Subgroup analysis on colonoscopies scheduled before 9 am showed that the two regimens have similar efficacy, suggesting that the DBL regimen may be a valuable alternative to the SD regimen for very early morning colonoscopies. |
EUS-guided gallbladder drainage vs dual stent transpapillary gallbladder drainage for management of acute cholecystitis. This study demonstrates that DSET-GBD has similarly low rates of recurrent acute cholecystitis compared with EUS-GBD. DSET-GBD should be considered as an alternative management strategy for management of acute cholecystitis in patients who are unable to undergo CCY. |
EUS-guided rendezvous is a viable salvage technique for failed billiary cannulation in patients with Roux-en-Y gastric bypass undergoing BAE-ERCP. EUS-RV in patients with RYGB has high technical and clinical success and can be a viable alternative to more invasive options when BAE-ERCP fails using traditional cannulation techniques. |
Efficacy and safety of H-APC in Barrett's esophagus: Italian prospective multicenter study. Regarding tolerability, mean pain score was 1.3 (SD 1.99) whereas mean dysphagia score was 1.28 (SD 0.56). The H-APC technique showed promising results in terms of effectiveness and safety with good tolerability in achieving initial CE-IM and CE-D in a selected population of BE patients. |
Endoscopic and clinical characteristics of autoimmune atrophic gastritis: Retrospective study. This study offers insights into the clinical, laboratory, and magnifying endoscopic features of patients with AIG. It demonstrates the three main magnifying endoscopic appearances of AIG and highlights the significant prevalence of gastric neoplasia, even in the low-risk Western population. These findings emphasize the importance of the endoscopic exam in identifying AIG and notably present the key magnifying endoscopy findings in a Western setting for the first time. |
Endoscopic blind limb reduction with septotomy for the treatment of candy cane syndrome after Roux-en-Y gastric bypass: Pilot feasibility study. EBLR may be a potentially safe, efficacious, and cost-effective alternative to surgery in patients with CCS. Further prospective studies are needed. |
Endoscopic mucosal resection defect inspection for predicting recurrences: International image-based survey. This study shows that recurrences after presumed complete EMR can reasonably well be predicted by both experienced and less experienced endoscopists when evaluating images with mucosal defects. Thorough inspection of the post-EMR defect may reduce recurrence rates by recognizing and subsequent treatment of suspect areas. |
Endoscopic transpapillary gallbladder drainage is associated with favorable long-term outcomes in patients with advanced liver disease. Transpapillary gallbladder stenting is technically feasible and associated with high rates of clinical success in patients with decompensated liver disease. Stone resolution is common after transpapillary gallbladder stenting and may portend favorable patient outcomes. |
Endoscopic transpapillary gallbladder stenting vs percutaneous cholecystostomy for managing acute cholecystitis: Nationwide propensity score study. ERCP was consistently associated with lower rates of post-procedural AEs compared with PCT including acute hypoxemic respiratory failure ( P < 0.001), acute renal failure ( P < 0.001), shock ( P < 0.001), and need for blood transfusions ( P < 0.001). Our nationwide analysis revealed that ERCP-guided gallbladder drainage should be the preferred approach for managing acute cholecystitis when unfit for surgery. |
Feasibility of a novel 5F plastic stent in endoscopic transpapillary gallbladder drainage for acute cholecystitis. The median time to late AE was 238 days for the 7F group and 187 days for the 5F group, with no significant difference. A 5F stent can provide outcomes comparable to those of a 7F stent and help prevent hyperamylasemia. |
Gender disparity in hepatobiliary endoscopy training and delivery: Results of a nationwide survey. Gender disparity in HPB endoscopy exists and is stark. Underlying this are attitudes, assumptions, and environmental factors that will require systemic and sustained correction. Ideas about how to address this challenge need to be explored. |
Hybrid percutaneous endoscopic gastrostomy (Hybrid PEG) improves patient safety by combining pull-through technique with gastropexy. Hybrid PEG and direct puncture are equally safe PEG insertion techniques, with significantly better safety profiles than the pull-through technique. Despite the retrospective design of the study, these results suggest preferential use of hybrid PEG due to handling. |
Improvement in adenoma detection rate by artificial intelligence-assisted colonoscopy: Multicenter quasi-randomized controlled trial. AI-assisted colonoscopy significantly increased ADR by 12.5% overall, with a notable 16.3% increase in the screening population. The unchanged NNRR indicates that the higher PDR was due to increased ADR, not unnecessary resections. |
Ingestible sensor capsule with extended battery capacity allows early diagnosis of GI malignancy in comorbid patients with occult bleeding and anemia. The second generation with an extended battery capacity of 9 hours opens the possibility of detecting blood in the middle and lower gastrointestinal tract. Herein we report another advantage of the extended battery capacity allowing noninvasive bleeding detection in the middle and lower gastrointestinal tract, leading to early endoscopic diagnosis of gastrointestinal malignancies with occult bleeding in comorbid patients with severe anemia. |
Novel device for blunt dissection in third space endoscopy: Preliminary animal study (with video). Blunt dissection using our device was feasible, safe, and potentially effective in third space endoscopy procedures by shortening operating time, reducing submucosal injections, and potentially minimizing muscle layer injury. |
Optimizing duodenal tissue acquisition for mechanistic studies of duodenal ablation in type 2 diabetes. Duodenal cold snare resection is safe and can provide high-quality tissue for optimally oriented TMAs and high-quality tissue dissociation scores for scRNA-seq (, NCT06333093, NCT05984238). This approach will allow mechanistic studies about the effects of duodenal ablation on metabolic syndrome and T2D. |
Pediatric cylindrical battery ingestion. According to our study data, conservative management may be advised for the majority of cases of CB ingestion. However, we acknowledge that CB should be timely removed whenever they are A23 or A27 type, damaged prior to ingestion, in cases of multiple ingestion, whenever retained in the stomach for a prolonged period, or whenever a child complains about any clinical signs or symptoms or had undergone prior abdominal surgery. |
Real-world effectiveness and safety of 1L polyethylene glycol and ascorbic acid for bowel preparation in patients aged 80 years or older. At least one AE was experienced by 4.5% of participants, the most frequent being mild dehydration (2.8%) and nausea (1.2%). This post-hoc analysis confirms 1L PEG-ASC to be an effective and safe bowel cleansing preparation for patients aged 80 years or older in a real-world setting. |
Reassessment reveals underestimation of infiltration depth in surgical resection specimens with lymph-node positive T1b esophageal adenocarcinoma. Our findings highlight the potential for underestimating tumor depth of invasion and other high-risk features in surgical specimens. Despite the limited cohort size, our study confirmed a consistent high-risk histological profile across al cases. Caution is warranted when extrapolating LNM risk data from historic heterogeneous cross-sectional surgical cohorts to the modern ER era. |
Sustained success in endoscopic performance demonstrated by the Irish National Endoscopy Quality Improvement Programme. Sustaining this improvement and continuing to capture national endoscopic performance will remain a core role of the Irish NEQI program. Workforce imbalances and minimum annual volumes continue to represent challenges for national endoscopy programs. |
Technical outcomes between a drill dilator and ultra-tapered mechanical dilator during EUS-guided pancreaticogastrostomy: Comparative study. Mean procedure time was shorter in the Tornus ES group (13.38±3.80 min) compared with the ES dilator group (21.40±1.54 min) ( P =0.0013). In conclusion, Tornus ES might be considered as the initial dilation device during EUS-PGS. |
Useful treatment selection strategy for endoscopic hemostasis in colonic diverticular bleeding according to endoscopic findings (with video). Direct clipping when placement of clips at the bleeding point is feasible and EBL when direct clipping is not feasible is a reasonable strategy in terms of effectiveness, efficiency, and safety. Selection of hemostatic method according to the visual field of SRH and maneuverability of the endoscope allows the advantages of both methods to be realized. |
| Endoscopy |
Biliary drainage prior to pancreatoduodenectomy with Endoscopic Ultrasound-guided choledochoduodenostomy vs conventional Endoscopic Retrograde Cholangiopancreatography: a propensity score matched study and surgeon-survey. This early experience suggests that preoperative biliary drainage with EUS-CDS does not increase the rate of complications after pancreatoduodenectomy and only infrequently hampers surgical exploration. |
Endoscopic Vacuum Therapy for the Management of Non-Variceal Upper Gastrointestinal Bleeding: A Valuable Resource for the Endoscopist's Toolbox. EVT appears to be safe and effective in the management of NVUGIB. This approach could be particularly useful in refractory or diffuse bleeding. Larger studies are warranted to validate these findings. |
Endoscopic ultrasound-guided tissue sampling: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review. MIAB could represent the first choice for smaller lesions (<20 mm) if proper expertise is available. ESGE does not recommend the use of antibiotic prophylaxis before EUS-guided tissue sampling of solid masses and EUS-FNA of pancreatic cystic lesions. |
Impact of Endoscopic Ultrasound-guided biliary drainage on the management of difficult biliary cannulation in patients with distal malignant biliary obstruction. The risk of AEs is higher in patients with DMBO, and DBC, this appears to be mainly related to the advanced cannulation techniques. In patients with dilated CBD (>12mm) "early" EUS-BD may minimize the risk of adverse events. |
Leaving colorectal polyps in situ with endocytoscopy assisted by computer-aided diagnosis: a cost-effectiveness study. Both endoscopist-alone and CADx-assisted optical diagnosis reduce colonoscopy costs. The risk of missed adenomas and surveillance interval deviations appear marginal. |
Reversible endoscopic gastroduodenal bypass: Endoscopic ultrasound-guided gastro-jejunostomy with pyloric exclusion for the treatment of persistent duodenal leaks after failed surgical repair. REGB is a technically feasible, reversible, and minimally invasive alternative for managing post-surgical duodenal leaks. Further studies are needed to validate its safety and efficacy. |
| Gastroenterology |
Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized Trial. EA was superior to SA and standard care only for reducing POI duration and the risk of prolonged POI in patients undergoing laparoscopic gastrectomy for gastric cancer (Trial number ChiCTR2100050660). |
Psychological stress-induced local immune response to food antigens increases pain signaling across the gut in mice. Psychological stress induces a type 2 immune response to food antigens, with IgE-mediated mast cell activation and increased pain signaling in the small intestine and colon in response to food. These findings may explain the potential role of psychological stress in food-induced symptoms in IBS. |
| Gastrointest Endosc |
Natural course of high-grade dysplasia in Barrett's esophagus: a scoping review and case-series. The lag-time between the diagnosis of HGD and progression to clinically-evident EAC varied from 1.5 to 10 years. EET for BE with HGD in patients with less than 3 years of life expectancy seems unlikely to be beneficial. These results may guide management decisions for patients with BE. NL7039; CRD42022362088. |
Safety of Same-Day Discharge After Gastric Peroral Endoscopic Myotomy in Patients with Refractory Gastroparesis: An International Multi-Center Study. G-POEM is safe with low incidence of AEs and 15-day readmission rates. SDD appears safe in uncomplicated cases, suggesting that upper gastrointestinal studies post-G-POEM may be unnecessary. |
| Gut |
E-twenty-six-specific sequence variant 5 (ETV5) facilitates hepatocellular carcinoma progression and metastasis through enhancing polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC)-mediated immunosuppression. ETV5 facilitates HCC progression and metastasis by promoting the recruitment, infiltration and activation of PMN-MDSCs. Synergistic application of anti-S100A9 or TLR4/RAGE inhibitors with anti-PD-L1 therapy holds great promise as an effective combinational treatment strategy for ETV5-positive HCC. |
Gene score to quantify systemic inflammation in patients with acutely decompensated cirrhosis. ACLF developed during hospitalisation in 80% of patients with a CLIF-SIG score >0.386 on admission. In patients with ADC, the CLIF-SIG score is an accurate estimator of SI, clinical course severity and prognosis. |
Multicentre randomised controlled trial of a self-assembling haemostatic gel to prevent delayed bleeding following endoscopic mucosal resection (PURPLE Trial). The application of a haemostatic gel following EMR of large flat lesions in the duodenum and colorectum does not reduce the rate of delayed bleeding. |
Serological screening for coeliac disease in an adult general population: the HUNT study. The TG2 IgA assay showed excellent abilities as a screening tool for CeD in the adult general population. However, the diagnostic accuracy of TG2 IgG was too poor for selectively identifying individuals with CeD. |
| Hepatology |
Assessment of liver injury potential of investigational medicines in drug development. While these approaches have been successful in dramatically reducing the marketing approval of medications eventually associated with hepatotoxicity, many challenges remain in identifying the risk for DILI during preclinical and early-to-late clinical development stages for genetic medicines, biological agents, and immunotherapies. In this review, we discuss current preclinical, in-silico, and clinical development approaches to screen for DILI potential of an investigational agent and provide a high-level description of regulators' approach for assessing DILI risk in an NDA. |
Integrative transcriptome profiling elucidates molecular and immunovascular characteristics of macrotrabecular hepatocellular carcinoma. Single-cell analysis has deepened our understanding of the molecular mechanism and tumor microenvironment in aggressive HCC. The combination of targeting tumor vasculature and blocking immune checkpoints represents a promising therapeutic strategy for this subtype. |
Repression of the ERRγ-CYP2E1 pathway by fibroblast growth factor 4 mitigates alcoholic liver injury. Our study identifies FGF4 as a stress-responsive regulator in liver pathophysiology, operating via an FGFR4-mediated ERRγ-CYP2E1 signaling pathway. These results underscore the potential of FGF4 and its downstream pathways as therapeutic targets for ALD treatment. |
Selective genetic inactivation of Caspase 8 in hepatocytes ameliorates progression of MASH following Jnk deficiency. This process is mainly mediated by Caspase 8-dependent apoptosis, thereby discovering that Caspase 8 is a downstream target of JNK½. Caspase 8 directed therapy in hepatocytes might be a promising treatment for patients with an increased oxidative stress response and MASH. |
Spatial single-cell proteomics landscape decodes the tumor microenvironmental ecosystem of intrahepatic cholangiocarcinoma. Furthermore, a spatial TME deep learning system was developed to predict the prognosis of iCCA patients with high accuracy from a single 1-mm2 tumor sample. This study offers preliminary insights into the spatial TME ecosystem of iCCA, providing valuable foundations for precise patient classification and the development of personalized treatment strategies. |
β-Catenin regulates distinct pathways from YAP and suppresses ONECUT1 to drive hepatoblastoma development in mice and humans. We show that suppressing activated β-Catenin could hamper HB progression in vivo by affecting pathways distinct from those regulated by YAP in HB. Inhibition of ONECUT1 expression by β-Catenin might represent a critical molecular event leading to HB formation. |
| J Hepatol |
Developing splice-switching oligonucleotides for urea cycle disorder using an integrated diagnostic and therapeutic platform. Specifically, we focus on CD, going from the discovery of a novel splice variant in the SLC25A13 gene with our novel UCD Deep Intronic-Gene Panel, to the development and in vivo validation of an efficacious SSO candidate for the pathogenic splice variant. We envision the possibility of extrapolating this pipeline to the diagnosis and development of treatments for other rare genetic diseases. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
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| Endosc Int Open |
| Gastroenterology |
Exercise, Gut Microbiome, and Gastrointestinal Diseases: Therapeutic Impact and Molecular Mechanisms. Future efforts should concentrate on gaining a deeper understanding of the factors involved in exercise-gut interactions through the generation of functional 'omics readouts (ie, metatranscriptomics, metaproteomics, and metabolomics) that have the potential to identify functional traits of the microbiome that are linked to host health and disease states, and validating these interactions in experimental and preclinical systems. A greater understanding of how PA interacts with the GI tract and the microbiome may enable targeted therapeutic strategies to be developed for individuals and populations at risk for a variety of GI diseases. |
| Gut |
RNA-based therapies in liver metabolic diseases. Despite their potential, the high costs of RNA therapies pose a challenge that will require cost-utility models to guide pricing and accessibility. Here, we discuss the fundamental aspects of RNA-based therapeutics and showcase the most relevant preclinical and clinical developments in genetic liver metabolic diseases. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
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| Endosc Int Open |
| Endoscopy |
| Gastroenterology |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
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| Gut |
| J Hepatol |